• ISSN: 0972-8546
  • |
  • NAAS Rating (Scientific Journals): 3.63

Plant Science Research, Vol. 38 2016, Pages : 50-54

Saktishree Jena, Sanhita Padhi, Rageshree Swain and Pragyan P. Rout

Herbal antidotes: A possible replacement for serum antivenom with effective lead compound using bioinformatics tools

Anti snake venom serum is the only rescue method in health centerswhen there is a fatal snake  bite condition. And these anti venoms derived from animal tissues are not properly designed  so they have a lot of side effects like anaphylaxis and even a high dose can be fatal. So instead  of serum anti venom, various plant products can be used which have less side effects. These  plant extracts must be tested in silico with their structure for effective proper binding with the  target venom protein. These herbal antidotes must be designed in such a way that it can target  the venom protein. To know the exact lead compound which can act upon that protein,  Bioinformatics tools are used as a starting point for in silico lead compound development. Toxic  protein are downloaded from PDB site and are docked with probable lead compound and based  on the docking respective lead compounds are screened. This is an attempt to show the  probable lead compounds extracted from plants which can act upon various venom proteins  and can be a probable cure for wide ranges of snake bites. 



Full Text PDF