Strychnos nux-vomica, an important wild medicinal plant of Odisha, was evaluated for the possible bioactive compounds through qualitative screening and thin layer chromatography (TLC). The Minimum Inhibitory Concentration (MIC) was determination for the anti-microbial activity of its leaf extracts (n-hexane, acetone, methanol and aqueous) against five bacterial strains (Streptococcus pyogenes, Streptococcus mutans, Shigella flexnerii, Salmonella enterictyphii and Vibrio cholerae) and two fungal strains (Candida parapsilosis and Aspergillus tubingensis). The results of phytochemical screening revealed the presence of saponin, tannin, alakaloids, flavonoids, phenolic compounds, steroids and terpenoids in the leaf extracts. With n-hexane and aqueous extracts, the MIC of 400 μg/ml was found effective against Streptococcus pyogenes, Shigella flexnerii and Candida parapsilosis. TLC showed visible bands with aqueous and n-hexane extracts. The results of the present study corroborates the claims of tribals and traditional healers about the use of S. nuxvomica for the treatment of bacterial and fungal infections.
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